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Association between IL-1β polymorphisms and gastritis risk: A meta-analysis
Xiaoming Sun1, Hongxing Cai, Zhouru Li
1Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Institute of Viral Disease Center for Molecular Medicine, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, P. R. China.
Interleukin-1 beta (IL-1β) gene polymorphisms may influence gastritis risk. Specifically, IL-1β-31 single nucleotide polymorphisms show a potential association with gastritis, particularly in Caucasians.
Area of Science:
- Genetics and Molecular Biology
- Gastroenterology
- Immunology
Background:
- Helicobacter pylori infection causes chronic gastric inflammation.
- Interleukin-1 beta (IL-1β) is implicated in H. pylori-induced gastritis pathology.
- Previous studies on IL-1β polymorphisms (rs16944 and rs1143627) and gastritis risk are inconsistent.
Purpose of the Study:
- To conduct a meta-analysis assessing the association between IL-1β polymorphisms and gastritis susceptibility.
Main Methods:
- Meta-analysis of 12 case-control studies (2205 cases, 2289 controls).
- Estimated odds ratios and 95% confidence intervals for IL-1β-511 and IL-1β-31 polymorphisms.
- Assessed heterogeneity, publication bias, and performed sensitivity analyses.
Main Results:
- Evidence suggests IL-1β-31 single nucleotide polymorphisms (SNPs) are associated with gastritis risk.
- This association appears stronger in the Caucasian population.
- IL-1β-511 SNPs did not show a significant association with gastritis risk.
Conclusions:
- IL-1β-31 polymorphisms may contribute to gastritis susceptibility.
- Findings could aid future gastritis disease monitoring.
- Further research into molecular mechanisms may guide interventions for susceptible groups.
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