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Long-term mortality after poisoning with antipsychotics.

Stine Toft¹, Henrik Horwitz¹, Kim Peder Dalhoff¹

¹a Department of Clinical Pharmacology , Bispebjerg and Frederiksberg University Hospital , Copenhagen , Denmark.

Clinical Toxicology (Philadelphia, Pa.)

|February 4, 2017

Summary

Antipsychotic poisoning significantly increases long-term mortality risk, with many deaths being preventable. This underscores the critical need for better support and secondary prophylaxis after suicide attempts involving these medications.

Keywords:

Antipsychotic poisoning deliberate self-poisoning long-term mortality

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Area of Science:

Pharmacovigilance
Public Health
Clinical Toxicology

Background:

Antipsychotic medications are widely prescribed, necessitating an understanding of their safety profile beyond acute overdose.
Deliberate self-poisoning incidents require thorough investigation into associated long-term health outcomes.

Purpose of the Study:

To determine the long-term mortality rates and causes of death following antipsychotic self-poisoning.
To assess the risk of recurrent self-poisoning episodes after an initial event involving antipsychotics.

Main Methods:

Utilized the Danish Poison Information Centre Database to identify patients with antipsychotic poisoning.
Linked patient data with national health registries to track mortality and repeated poisoning events.

Main Results:

2289 patients were identified with antipsychotic poisoning between 2006-2013.
A significant increased standardized mortality ratio (9.0) was observed, with 150 deaths by 2014.
28% of patients repeated self-poisoning, and 50% of deaths were from natural causes.

Conclusions:

Antipsychotic self-poisoning is linked to a substantially elevated risk of mortality.
A significant proportion of these deaths are potentially preventable, highlighting a need for improved post-attempt care.
Secondary prophylaxis strategies are crucial for individuals who have attempted suicide by poisoning with antipsychotics.