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Updated: Mar 8, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Current Challenges and Opportunities in PD
Philip Kam-Tao Li1, Vickie Wai-Ki Kwong1
1CUHK Carol and Richard Yu PD Research Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.
Insights
Peritoneal dialysis (PD) offers renal replacement therapy but faces challenges like infections and technique failure. Further research and global guidelines can improve PD patient outcomes.
Area of Science:
- Nephrology
- Renal Replacement Therapy
Background:
- Peritoneal dialysis (PD) is increasingly used globally.
- Significant challenges impede long-term PD success and patient outcomes.
Purpose of the Study:
- To identify and address key areas needing improvement in peritoneal dialysis.
- To highlight strategies for enhancing PD patient care and outcomes.
Main Methods:
- Review of current challenges in PD.
- Discussion of potential solutions including research, education, and guidelines.
Main Results:
- Identified challenges include technique failure, infections, malnutrition, cardiovascular issues, volume overload, glucose exposure, solute removal adequacy, peritoneal access, physiological changes, patient fatigue, psychosocial factors, and elderly care.
- Hemodialysis also presents areas for improvement.
Conclusions:
- Continued clinical and basic science research is crucial.
- Enhanced education, training, and global PD guidelines are essential for resolving PD challenges.
- Improved PD patient outcomes are anticipated with these advancements.
Abstract:
Despite the gradual increased use of peritoneal dialysis (PD) globally around the world, it is recognized that a number of areas in PD as a renal-replacement therapy require attention and improvements. The current challenges in PD include how to tackle technique failure and sustain long-term PD, manage and prevent peritoneal infections, malnutrition and inflammation, cardiovascular mortality, volume overload, glucose exposure, adequacy of solute removal, peritoneal access, peritoneal physiology and changes with long-term PD, patient fatigue, psychosocial issues, and care of elderly patients on PD. Obviously, hemodialysis as another renal-replacement therapy modality also has its own areas that need attention and improvement by nephrologists and nurses. With more clinical and basic science research, outcome studies, and through better education and training, together with the implementation of global PD guidelines for enhancing care of PD patients, it is likely that such problem areas in PD gradually will be resolved and PD patient outcomes will be improved.
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