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A Demonstration of Mixing Robustness in a Direct Compression Continuous Manufacturing Process.

Wyatt J Roth1, Ahmad Almaya1, Timothy T Kramer2

  • 1Process Design and Development, Small Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285.

Journal of Pharmaceutical Sciences
|February 4, 2017
PubMed
Summary

Continuous mixing in direct compression manufacturing shows robustness. Higher flow rates improve tablet potency and content uniformity, with minimal impact on dissolution and physical attributes when feeders are controlled.

Keywords:
compressioncontent uniformitydissolutionformulationmixingpowder technologyprocessingsolid dosage formtabletingunit operations

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