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Updated: Mar 8, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

CD19, from bench to bedside.

Xinchen Li¹, Ying Ding¹, Mengting Zi¹

¹Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Science, Anhui Normal University, Anhui, China.

Immunology Letters

|February 4, 2017

Summary

This summary is machine-generated.

CD19, a B cell surface molecule, acts as both a positive and negative regulator of B cell antigen receptor (BCR) signaling. Dysregulated CD19 expression is linked to autoimmune diseases and B cell lymphomas, highlighting its critical role.

Keywords:

Autoimmunity B cell lymphomas BCR CD19 Signal transduction

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Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

CD19 is a 95-kDa immunoglobulin superfamily member found exclusively on B lymphocytes.
It functions as a critical co-receptor for B cell antigen receptor (BCR) signal transduction.
CD19 co-ligation with BCR enhances calcium release, MAPK activity, and cell proliferation.

Purpose of the Study:

To review the dual roles of CD19 in BCR signaling.
To explore CD19's function as both a positive and negative regulator.
To highlight the link between disturbed CD19 expression and B cell-related diseases.

Main Methods:

Literature review of recent developments in CD19 research.
Analysis of CD19's signaling pathways.
Correlation studies between CD19 expression and disease states.

Main Results:

CD19 exhibits context-dependent positive and negative regulatory functions in BCR signaling.
CD19 deficiency can lead to hyper-responsiveness in certain conditions.
Abnormal CD19 expression is associated with autoimmune diseases and B cell lymphomas.

Conclusions:

CD19 plays a complex, dual role in B cell signaling.
Understanding CD19's mechanistic insights is crucial for both physiological and pathological conditions.
Disturbed CD19 expression has significant implications for B cell-related diseases.