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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.8K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.2K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

10.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

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Related Experiment Video

Updated: Mar 8, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Notch as a tumour suppressor.

Craig S Nowell1, Freddy Radtke2

  • 1CMU, Department for Pathology and Immunology, University of Geneva, Rue Michel Servet, 1211 Geneva 4, Switzerland.

Nature Reviews. Cancer
|February 4, 2017
PubMed
Summary
This summary is machine-generated.

The Notch signalling pathway is crucial for development and homeostasis. This review highlights its tumor-suppressive roles in cancer and potential therapeutic strategies targeting Notch for cancer treatment.

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Related Experiment Videos

Last Updated: Mar 8, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Oncology

Background:

  • The Notch signalling pathway is an evolutionarily conserved signaling cascade vital for development and tissue homeostasis.
  • Its role is multifaceted and context-dependent, influencing diverse cellular processes.
  • Aberrant Notch activity is implicated in cancer initiation and progression, acting as either oncogenic or tumor-suppressive.

Purpose of the Study:

  • To review the latest developments in the tumor-suppressor activity of Notch signalling.
  • To discuss potential mechanisms by which Notch inhibits carcinogenesis.
  • To highlight therapeutic strategies for restoring or augmenting Notch-mediated tumor suppression.

Main Methods:

  • Literature review of recent research on Notch signalling in cancer.
  • Analysis of studies investigating Notch's tumor-suppressive functions.
  • Exploration of potential therapeutic interventions targeting the Notch pathway.

Main Results:

  • Notch signalling exhibits context-dependent tumor-suppressive activity in various tissues.
  • Mechanisms of Notch-mediated carcinogenesis inhibition are diverse and tissue-specific.
  • Restoring or enhancing Notch activity presents a promising therapeutic avenue for cancer treatment.

Conclusions:

  • The Notch pathway's tumor-suppressor functions are a critical area for cancer research.
  • Targeting Notch signalling holds significant therapeutic potential for multiple cancer types.
  • Further investigation into Notch-mediated tumor suppression can lead to novel cancer therapies.