Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Therapy01:28

Drug Therapy

353
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
353
Clinical Trials01:16

Clinical Trials

11.0K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.0K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

335
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
335
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

300
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
300
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

196
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
196
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

66
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
66

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One Pivotal Trial for FDA Approval - Ending the Two-Trial Dogma.

The New England journal of medicine·2026
Same author

From Global Impact to Pharmacoequity: A Call to Action for Clinical Pharmacology.

Clinical pharmacology and therapeutics·2026
Same author

Guideline for the Measurement, Analysis and Reporting of Medication Adherence during the Run-in phase of clinical trials (MARMAR).

Trials·2026
Same author

Eye care adherence in pediatric and elderly: Understanding and addressing the challenges.

Progress in retinal and eye research·2026
Same author

Estimating hypertension medication adherence among adults using linked Belgian health interview survey and administrative pharmacy refill data.

BMC public health·2026
Same author

Treating Pregnant and Lactating Women: Insights from Clinical Pharmacology.

Annual review of pharmacology and toxicology·2026

Related Experiment Video

Updated: Mar 8, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.3K

Poor medication adherence in clinical trials: consequences and solutions.

Alasdair Breckenridge1, Jeffrey K Aronson2, Terrence F Blaschke3

  • 1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK.

Nature Reviews. Drug Discovery
|February 4, 2017
PubMed
Summary

Poor adherence to medicines in clinical trials can negatively impact trial results and estimations of drug benefits and risks. This article discusses these consequences and proposes solutions to improve patient adherence.

More Related Videos

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

14.1K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.3K
Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

14.1K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K

Area of Science:

  • Clinical research methodology
  • Pharmacovigilance
  • Patient compliance studies

Background:

  • Patient adherence to medication is crucial for the validity of clinical trials.
  • Non-adherence can significantly skew results regarding drug efficacy and safety.
  • Undermining trial value leads to unreliable data on benefits and risks.

Purpose of the Study:

  • To highlight the negative consequences of poor medicine adherence in clinical trials.
  • To discuss strategies for improving patient adherence in research settings.

Main Methods:

  • Literature review on adherence challenges in clinical trials.
  • Analysis of the impact of non-adherence on trial outcomes.
  • Exploration of interventions to enhance patient compliance.

Main Results:

  • Poor adherence compromises the accuracy of benefit-risk assessments.
  • It can lead to incorrect conclusions about a drug's performance.
  • Methods to improve adherence are essential for trial integrity.

Conclusions:

  • Addressing poor medicine adherence is vital for maintaining the integrity and value of clinical trials.
  • Implementing targeted strategies can improve patient compliance and ensure reliable trial data.