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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

94
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

80
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
73

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Related Experiment Video

Updated: Mar 8, 2026

Measuring Local Anaphylaxis in Mice
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Anaphylaxis caused by honey: a case report.

Rita Aguiar1, Fátima Cabral Duarte1, Ana Mendes1

  • 1Department Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, E.P.E, 1649-035 Lisbon, Portugal.

Asia Pacific Allergy
|February 4, 2017
PubMed
Summary

Honey allergy is a rare but serious condition. A patient experienced anaphylaxis during allergy testing, highlighting the risks of honey-induced allergic reactions.

Keywords:
AnaphylaxisHoneyPrick-to-prick test

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Area of Science:

  • Allergy and Immunology
  • Food Science

Background:

  • Honey allergy is an uncommon but potentially severe health issue.
  • Increased consumption of honey in health foods may lead to more allergic reactions.

Observation:

  • A case study involving one patient who experienced anaphylaxis.
  • The reaction occurred during a honey allergological investigation using a skin prick-prick test.

Findings:

  • The patient exhibited anaphylaxis following skin prick-prick testing with honey.
  • This suggests a significant allergic response to honey in susceptible individuals.

Implications:

  • Highlights the importance of caution during honey allergy testing.
  • Suggests a potential rise in honey-related allergies due to increased honey consumption.