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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Mar 8, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Parkinson's disease as a multisystem disorder.

Lisa Klingelhoefer1, H Reichmann2

  • 1Department of Neurology, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany. lisa.klingelhoefer@uniklinikum-dresden.de.

Journal of Neural Transmission (Vienna, Austria : 1996)
|February 4, 2017
PubMed
Summary

Professor Jellinger

Keywords:
Alpha-synucleinNMSNon-motor symptomsPDParkinson’s diseaseProteinopathy

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Area of Science:

  • Neuroscience
  • Neuropathology

Background:

  • Parkinson's disease (PD) involves multiple body and neurotransmitter systems.
  • Neuropathological hallmarks include phosphorylated alpha-synuclein and Lewy pathology.

Purpose of the Study:

  • To summarize Professor Jellinger's contributions to understanding Parkinson's disease.
  • To elucidate the pathological spread and systemic effects in PD.

Main Methods:

  • Review of Professor Jellinger's work on Parkinson's disease.
  • Analysis of neuropathological findings and symptom progression.

Main Results:

  • PD pathology, including Lewy bodies, may originate in the enteric nervous system and olfactory bulb.
  • Pathology spreads rostrocranially to the central nervous system (CNS).
  • Progressive degeneration of the nigrostriatal system and extranigral pathology cause diverse motor and non-motor symptoms.

Conclusions:

  • Parkinson's disease is a multi-system disorder with a distinct pathological progression.
  • Understanding the spread of pathology is key to comprehending PD's complex symptomatology.