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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
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Patent highlights August-September 2016.

Hermann Am Mucke1

  • 1HM Pharma Consultancy, Enenkelstr. 28/32, A-1160 Wien, Austria.

Pharmaceutical Patent Analyst
|February 4, 2017
PubMed
Summary

Recent patent literature highlights key advancements in pharmaceutical and medical research. These developments offer insights into emerging trends and innovations in drug discovery and healthcare technologies.

Area of Science:

  • Pharmaceutical sciences
  • Medical technology
  • Intellectual property law

Background:

  • The patent landscape is crucial for understanding innovation trajectories.
  • Tracking patent filings reveals emerging trends in R&D.
  • Intellectual property protection drives investment in medical advancements.

Purpose of the Study:

  • To provide a concise overview of recent significant patent developments.
  • To identify key areas of innovation in pharmaceutical and medical R&D.
  • To highlight patents relevant to ongoing research and development.

Main Methods:

  • Systematic review of recent patent literature.
  • Analysis of patent filings in pharmaceutical and medical fields.
  • Categorization of patents based on technological relevance.

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Main Results:

  • Identification of novel therapeutic targets and drug delivery systems.
  • Emerging patents in diagnostic tools and medical devices.
  • Trends in regenerative medicine and personalized healthcare patents.

Conclusions:

  • The patent literature reflects dynamic innovation in drug discovery and medical devices.
  • Recent patents underscore the growing importance of personalized medicine and advanced diagnostics.
  • Monitoring patent activity is essential for strategic R&D planning.