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Excessive angiogenesis associated with psoriasis as a cause for cardiovascular ischaemia

Nina Malecic1, Helen S Young1

  • 1Manchester Academic Health Science Centre, Department of Dermatology, The University of Manchester, Manchester, UK.

Experimental Dermatology
|February 4, 2017
PubMed

Insights

Psoriasis patients show increased angiogenesis, driven by vascular endothelial growth factor (VEGF). This process may link skin disease to cardiovascular events and offer new therapeutic targets.

Area of Science:

  • Dermatology and Cardiovascular Research

Background:

  • Psoriasis affects 2-3% of the UK population, causing significant quality of life impairment.
  • Psoriasis is linked to cardiovascular comorbidity and metabolic syndrome.
  • Angiogenesis is implicated in psoriasis pathogenesis and atherosclerosis development.

Purpose of the Study:

  • To explore the role of vascular endothelial growth factor (VEGF)-mediated angiogenesis in psoriasis.
  • To investigate angiogenesis as a potential marker for systemic vascular pathology in psoriasis patients.
  • To examine VEGF-mediated angiogenesis as a therapeutic target for cardiovascular events in psoriasis.

Main Methods:

  • This viewpoint study reviews existing research on angiogenesis in psoriasis.
  • It focuses on the role of vascular endothelial growth factor (VEGF).

Main Results:

  • Vascular endothelial growth factor (VEGF) is upregulated in psoriasis.
  • Pathological angiogenesis, mediated by VEGF, is a key factor in psoriasis.
  • Cutaneous angiogenesis may serve as a marker for systemic vascular pathology.

Conclusions:

  • VEGF-mediated angiogenesis is a significant factor in psoriasis.
  • It may contribute to cardiovascular events in psoriasis patients.
  • Targeting angiogenesis presents a novel therapeutic avenue for psoriasis and associated cardiovascular conditions.

Keywords:
angiogenesisatherosclerosiscardiovascular diseasepsoriasisvascular endothelial growth factor

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