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Long-term prognostic role of CA-125 in noncongestive patients undergoing a cardiac transplantation
Víctor Manuel Becerra-Muñoz1, José Manuel Sobrino-Márquez2, Diego Rangel-Sousa2
1Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), CIBERCV Enfermedades Cardiovasculares, Málaga, Spain.
Insights
Elevated CA-125 levels in chronic heart failure patients predict poorer long-term survival after cardiac transplantation (CT). This biomarker indicates a higher risk of mortality post-transplant.
Area of Science:
- Cardiology
- Biomarkers
- Transplantation Immunology
Background:
- Chronic heart failure (CHF) significantly impacts long-term patient prognosis.
- Cardiac transplantation (CT) is a critical treatment option for end-stage heart failure.
- Identifying reliable prognostic markers post-CT is essential for patient management.
Purpose of the Study:
- To investigate the association between elevated CA-125 levels and long-term outcomes in patients following CT.
- To determine if CA-125 serves as an independent predictor of mortality after cardiac transplantation.
Main Methods:
- Retrospective analysis of 55 patients who underwent CT with pre-existing CA-125 measurements.
- Exclusion of patients with congestive complications or survival less than one year post-CT.
- Statistical analysis to assess the correlation between CA-125 levels and long-term survival rates.
Main Results:
- 23 out of 55 patients exhibited elevated CA-125 levels (>35 U/ml).
- Patients with high CA-125 showed significantly inferior survival rates at 2, 5, and 8 years post-CT (p=0.014).
- Elevated CA-125 (>35 U/ml) was identified as an independent predictor of long-term mortality (OR: 3.94; p=0.023).
Conclusions:
- High CA-125 levels are associated with diminished long-term survival in noncongestive patients post-CT.
- CA-125 may serve as a valuable prognostic biomarker in cardiac transplant recipients.
- Further research could explore the clinical utility of CA-125 for risk stratification in CT patients.
Aim:
To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT).
Materials & Methods:
We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was <1 year after CT were excluded.
Results:
Of 55 patients, 23 had elevated CA-125 levels (>35 U/ml). After CT, survival was significantly inferior in this group (96.3 vs 81%, 84.9 vs 64%, 70.7 vs 32.9% at 2, 5 and 8 years, p = 0.014). CA-125 >35 U/ml was the only factor independently associated to long-term mortality (OR: 3.94; 95% CI: 1.2-12.82; p = 0.023).
Conclusion:
Noncongestive patients with high levels of CA-125 had inferior long-term survival after CT.
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