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Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for

Ibrahim R Khalil1,2, Alan T H Burns3, Iza Radecka4

  • 1Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK. Grazyna.Adamus@cmpw-pan.edu.pl.

International Journal of Molecular Sciences
|February 4, 2017
PubMed

Insights

Poly-γ-glutamic acid (γ-PGA) micro/nanoparticles show promise for drug delivery and as antimicrobial agents due to their biocompatibility and controlled release. This review covers γ-PGA

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Poly-γ-glutamic acid (γ-PGA) is a biodegradable, non-toxic, and non-immunogenic biopolymer produced by bacteria.
  • Its unique properties and carboxylic acid groups allow for conjugation with therapeutic agents.
  • γ-PGA has found applications in medical, food, and wastewater industries.

Purpose of the Study:

  • To review the structure, properties, and preparation methods of γ-PGA and its derivatives.
  • To highlight the impact of encapsulating antimicrobial and therapeutic agents within γ-PGA micro/nanoparticles.
  • To explore the potential of γ-PGA-based systems in drug delivery and antimicrobial applications.

Main Methods:

  • Literature review focusing on γ-PGA structure, properties, and synthesis.
  • Analysis of studies involving the micro/nanoencapsulation of active agents onto γ-PGA.
  • Examination of the controlled and sustained-release characteristics of γ-PGA formulations.

Main Results:

  • γ-PGA micro/nanoparticles offer controlled and sustained release of encapsulated agents.
  • These particles exhibit low toxicity and excellent biocompatibility with biological systems.
  • The carboxylic groups on γ-PGA facilitate the attachment and conjugation of various drugs and antimicrobials.

Conclusions:

  • γ-PGA-based micro/nanoparticles are highly promising for advanced drug delivery systems.
  • Their inherent biocompatibility and biodegradability make them suitable for biomedical applications.
  • Further research into γ-PGA derivatives can unlock new therapeutic possibilities.
Keywords:
antimicrobialdrug delivery systemγ-PGA

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