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Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors

Nuria Perretta-Tejedor1,2,3, Javier Fernández-Mateos3,4, Luis García-Ortiz1,3,5

  • 1Translational Research on Renal and Cardiovascular Diseases (TRECARD), Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain.

Scientific Reports
|February 4, 2017
PubMed

Insights

Genetic variations in VAV2 and VAV3 influence cardiovascular health. Specific VAV2 and VAV3 polymorphisms are linked to obesity, blood pressure, and target organ damage, offering new insights into cardiovascular disease risk factors.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Hypertension, diabetes, and obesity are key cardiovascular risk factors.
  • These conditions are closely linked to damage in renal and cardiovascular organs.
  • VAV2 and VAV3 proto-oncogenes regulate cardiovascular homeostasis via GTPase signaling.

Purpose of the Study:

  • To investigate the association between VAV2 rs602990 and VAV3 rs7528153 polymorphisms and cardiovascular risk factors.
  • To examine the relationship between these polymorphisms and target organ damage in the heart, vessels, and kidneys.
  • To explore potential sex-specific effects of these genetic variations on cardiovascular health.

Main Methods:

  • Analysis of 411 subjects to determine the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms.
  • Assessment of cardiovascular risk factors including obesity, blood pressure, and ankle-brachial index.
  • Evaluation of target organ damage, including retinal artery caliber and overall cardiovascular damage.

Main Results:

  • The T allele of VAV2 rs602990 is associated with increased obesity risk, lower ankle-brachial index, reduced diastolic blood pressure, and smaller retinal artery caliber.
  • Carriers of the VAV2 rs602990 T allele showed a higher risk of target organ damage in males.
  • The T allele of VAV3 rs7528153 is linked to decreased susceptibility to hypertension, diabetes, obesity, or cardiovascular damage, but an increased risk of altered basal glucose levels.

Conclusions:

  • This study is the first to report an association between VAV2 and VAV3 polymorphisms and cardiovascular risk factors.
  • VAV2 and VAV3 genetic variations may play a role in the development of cardiovascular disease and target organ damage.
  • These findings highlight the potential of VAV gene polymorphisms as biomarkers for cardiovascular risk stratification.

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