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Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer

Mingwei Chen1, Jianfa Li2, Chengle Zhuang3

  • 1Department of Urology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, Zhejiang, China.

Oncotarget
|February 4, 2017
PubMed

Insights

Long non-coding RNA ABHD11-AS1 is highly expressed in bladder cancer, promoting tumor growth and migration. This finding suggests ABHD11-AS1 could be a potential therapeutic target for treating bladder cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer remains a significant global health challenge with limited improvements in patient mortality despite advances in early detection.
  • Long non-coding RNAs (lncRNAs) are crucial regulators in biological processes, including tumorigenesis.
  • Previous studies indicated high expression of lncRNA ABHD11 Antisense RNA 1 (ABHD11-AS1) in gastric cancer.

Purpose of the Study:

  • To investigate the role of lncRNA ABHD11-AS1 in the development and progression of human bladder cancer.
  • To determine if ABHD11-AS1 expression correlates with clinicopathological features in bladder cancer patients.

Main Methods:

  • Quantitative real-time PCR was used to assess ABHD11-AS1 expression in bladder cancer tissues and cell lines.
  • Functional assays, including cell proliferation, migration, and apoptosis assays, were performed after silencing or overexpressing ABHD11-AS1.
  • Statistical analysis was used to correlate ABHD11-AS1 expression with clinicobiological features.

Main Results:

  • ABHD11-AS1 was found to be significantly upregulated in bladder cancer tissues and cell lines compared to normal controls.
  • Higher ABHD11-AS1 expression levels were positively associated with adverse clinicopathological features.
  • Silencing ABHD11-AS1 inhibited bladder cancer cell proliferation and migration while promoting apoptosis; conversely, overexpression had opposite effects.

Conclusions:

  • lncRNA ABHD11-AS1 acts as an oncogene in human bladder cancer.
  • ABHD11-AS1 may serve as a potential diagnostic biomarker and therapeutic target for bladder cancer.
Keywords:
ABHD11-AS1bladder cancerlncRNAsmigrationproliferation

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