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DNA-graphene interactions during translocation through nanogaps.

Hiral N Patel1, Ian Carroll1, Rodolfo Lopez1

  • 1Department of Physics and Astronomy, California State University Northridge, Northridge, California, United States of America.

Plos One
|February 4, 2017
PubMed
Summary

We investigated double-stranded DNA translocation through novel graphene nanogaps. DNA-graphene interactions are crucial for nanogap devices and single-molecule analysis.

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Area of Science:

  • Nanotechnology and Materials Science
  • Biophysics and Molecular Biology

Background:

  • Graphene nanogaps offer a promising platform for single-molecule detection.
  • Understanding DNA translocation through these nanostructures is key for developing advanced biosensing devices.

Purpose of the Study:

  • To investigate the translocation dynamics of double-stranded DNA through graphene nanogaps.
  • To explore the influence of nanogap geometry on DNA translocation signatures.
  • To analyze the electrical signals generated during DNA-graphene interactions.

Main Methods:

  • Fabrication of graphene nanogaps using a novel capillary-force induced technique.
  • Measurement of DNA translocation events through the fabricated nanogaps.
  • Analysis of translocation time, conductance variations, and current trace relaxation.

Main Results:

  • DNA translocation signatures in graphene nanogaps differ from those in nanopores due to distinct gap shapes.
  • Translocation time and conductance exhibit significant variations (∼100%), attributed to local gap width heterogeneity.
  • Observation of exponentially relaxing current traces, potentially due to graphene membrane relaxation post-translocation.

Conclusions:

  • DNA-graphene interactions are significant and must be accounted for in graphene-nanogap device design.
  • This research paves the way for direct reading of single-molecule activities.
  • Potential applications include advancements in DNA sequencing technologies.