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Convulsions induced by aminocaproic acid infusion
R Rabinovici1, A Heyman, Y Kluger
1Department of Surgery, Hadassah University Hospital, Jerusalem, Israel.
DICP : the Annals of Pharmacotherapy
|October 1, 1989
Summary
Aminocaproic acid, an antifibrinolytic, rarely causes serious adverse effects. A patient with cirrhosis experienced a seizure during intravenous aminocaproic acid treatment, highlighting a potential neurological risk.
Area of Science:
- Pharmacology
- Neurology
- Hepatology
Background:
- Aminocaproic acid is a common antifibrinolytic medication.
- It is frequently used to control bleeding.
- Serious adverse events are considered rare.
Observation:
- A case study involving a patient with liver disease and cirrhosis.
- The patient received intravenous aminocaproic acid.
- A grand mal seizure occurred during administration.
Findings:
- The patient had no prior history of neurological issues.
- Seizure is a potential, albeit rare, adverse effect of aminocaproic acid.
- Liver disease may influence the risk of neurological complications.
Implications:
- Clinicians must be aware of seizure risk with aminocaproic acid, especially in patients with liver disease.
- This finding suggests a need for careful monitoring in vulnerable patient populations.
- Further research may be warranted to understand the mechanism linking aminocaproic acid, liver disease, and seizures.