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Related Experiment Video

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Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
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Couples' body composition and time-to-pregnancy.

Rajeshwari Sundaram1, Sunni L Mumford2, Germaine M Buck Louis3

  • 1Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3232, Bethesda, MD 20892, USA.

Human Reproduction (Oxford, England)
|February 4, 2017
PubMed
Summary
This summary is machine-generated.

Obese class II couples (BMI ≥ 35 kg/m2) experience longer time-to-pregnancy (TTP) compared to normal BMI couples (BMI < 25 kg/m2). This association was observed when both partners' body mass index (BMI) were jointly modeled, highlighting the importance of couple

Keywords:
body mass indexcentral adiposityfertilityobesityprospective study

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Area of Science:

  • Reproductive Health
  • Human Fecundity
  • Body Composition Analysis

Background:

  • Extremes in Body Mass Index (BMI) are linked to longer time-to-pregnancy (TTP) and reduced success in assisted reproductive technology (ART).
  • Previous research has not extensively explored the combined impact of both partners' adiposity on prospectively measured TTP, despite pregnancy being a couple-dependent outcome.

Purpose of the Study:

  • To investigate the association between couples' body compositions and fecundity, measured by TTP.
  • To determine if joint modeling of partners' BMI provides a clearer understanding of its impact on TTP.

Main Methods:

  • A prospective cohort study enrolled 501 couples trying to conceive, followed for up to one year or until pregnancy.
  • Standardized anthropometric assessments (height, weight, waist, hip circumference) were conducted for both partners.
  • Discrete-time Cox regression analyzed fecundability odds ratios (FORs), controlling for confounders.

Main Results:

  • Individual partner BMI was not significantly associated with TTP.
  • Couples in obese class II (BMI ≥ 35.0 kg/m2) showed reduced fecundability (adjusted FOR = 0.41) compared to normal BMI couples (<25 kg/m2).
  • Higher female waist circumference (≥88.6 cm) was linked to reduced fecundability in unadjusted, but not adjusted, analyses.

Conclusions:

  • Jointly modeling couples' BMI reveals that obesity class II is associated with a longer TTP.
  • These findings emphasize the significance of considering both partners' body composition in preconception counseling.
  • Further research is needed to address potential residual confounding and generalizability to clinical populations.