[Genital vulvar lichen sclerosis in 2 siblings]

Area of Science:

• Dermatology
• Gynecology
• Genetics

Background:

• Lichen sclerosus is a chronic inflammatory skin condition affecting the vulva, primarily in postmenopausal women, but with a secondary peak incidence in pre-pubertal girls.
• The exact etiology remains unknown, though genetic predispositions, including Human Leukocyte Antigen (HLA) associations and familial clustering, are suggested.
• The condition is characterized by well-demarcated, white, atrophic plaques causing potential discomfort and cosmetic changes.

Observation:

• This report details the clinical course of vulval lichen sclerosus in two sisters who developed the condition almost simultaneously.
• Both individuals presented with symptoms consistent with lichen sclerosus of the vulva.

Findings:

• The sisters' vulval lichen sclerosus was effectively treated with a topical cream containing thyme extract.
• No adverse side effects were reported following the application of the thyme extract cream.

Implications:

• This case suggests that thyme extract may be a safe and effective treatment option for vulval lichen sclerosus, particularly in pediatric or adolescent populations.
• Further research into the efficacy and mechanism of action of herbal remedies like thyme extract for lichen sclerosus is warranted.
• The simultaneous occurrence in sisters underscores the potential role of genetic factors and warrants further investigation into familial predispositions.