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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
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Antiviral Treatments.

Michael G Ison1

  • 1Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue Suite 900, Chicago, IL 60611, USA.

Clinics in Chest Medicine
|February 5, 2017
PubMed
Summary
This summary is machine-generated.

Common respiratory viruses cause most infections, but some antivirals are no longer effective against influenza. Neuraminidase inhibitors are the only approved influenza treatments, while ribavirin aids immunosuppressed patients.

Keywords:
InfluenzaNeuraminidase inhibitorRespiratory syncytial virus (RSV)Respiratory virusRibavirin

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Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Viral respiratory tract infections are common, caused by various viruses.
  • Classic respiratory viruses include influenza, RSV, and rhinoviruses.
  • Opportunistic viruses like herpes simplex can also affect the respiratory tract.

Purpose of the Study:

  • To review the landscape of viral respiratory infections.
  • To discuss the efficacy and limitations of current antiviral therapies.
  • To highlight treatment options for specific patient groups.

Main Methods:

  • Literature review of viral respiratory infections.
  • Analysis of antiviral drug effectiveness.
  • Summary of treatment guidelines and outcomes.

Main Results:

  • Influenza A strains are resistant to M2 inhibitors (amantadine, rimantadine).
  • Neuraminidase inhibitors are the only approved antivirals for influenza.
  • Ribavirin, with intravenous antibody, shows efficacy in immunosuppressed patients.

Conclusions:

  • Antiviral resistance necessitates updated treatment strategies.
  • Neuraminidase inhibitors remain crucial for influenza management.
  • Ribavirin offers a therapeutic option for severe cases in immunocompromised individuals.