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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Respiratory Viral Infections in Chronic Lung Diseases
Clemente J Britto1, Virginia Brady2, Seiwon Lee2
1Adult Cystic Fibrosis Program, Section of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, Yale University, 300 Cedar Street, TAC S419, New Haven, CT 06513, USA; Section of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, Yale University, 300 Cedar Street, TACS441D, New Haven, CT 06513, USA.
Abstract:
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis (CF) and interstitial lung diseases (ILD), affect many individuals worldwide. Patients with these chronic lung diseases are susceptible to respiratory lung infections and some of these viral infections can contribute to disease pathogenesis. This review highlights the associations of lung infections and the respective chronic lung diseases and how infection in the different lung diseases affects disease exacerbation and progression.
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