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Updated: Aug 19, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
[Giant cell tumor of bone. An analysis of 69 cases]
P Wuisman1, A Härle, B Nommensen
1Orthop. Universitätsklinik, Münster/Westf.
Abstract:
1. The tumor stage of the giant cell tumor is an indicator for the prognosis and the need for adjuvant therapy. 2. Intralesional excisions without an adjuvant result in high rates of recurrence. 3. Polymethyl methyl acrylate (PMMA) largely prevents recurrences, provides stability and makes early functional treatment possible. 4. Broad excisions should only be performed in bone which is dispensable. 5. Recurrences frequently manifest themselves by pain. They can be removed intralesionally, as in primary therapy.
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