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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Can pan-allergens affect the sensitization pattern?

Giorgio Ciprandi1, Paola Comite2, Marco Bruzzone3

  • 1Internal Medicine Department, IRCCS-AOU San Martino-IST, Genoa, Italy.

Immunobiology
|February 5, 2017
PubMed
Summary
This summary is machine-generated.

Sensitization to a common allergen increases the likelihood of other allergies. The specific pattern of co-sensitization depends on the initial sensitizing allergen family, impacting allergy diagnosis.

Keywords:
Allergen-specific IgEGenoaPan-allergenSensitizationSerum

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Epidemiology

Background:

  • Pan-allergen sensitization, where an individual is allergic to multiple allergens sharing common protein structures, is increasingly recognized.
  • Understanding co-sensitization patterns is crucial for accurate allergy diagnosis and management.
  • The influence of specific pan-allergen families on co-sensitization patterns requires further investigation.

Purpose of the Study:

  • To investigate whether sensitization to a pan-allergen affects the overall sensitization pattern.
  • To determine if co-sensitization patterns are influenced by the specific pan-allergen family involved.

Main Methods:

  • Retrospective analysis of 1059 subjects (396 males, 663 females; mean age 42.8 years).
  • Selection of 22 common sensitization pattern allergens (SPA) in Genoa, Italy.
  • Focus on five target allergens (TA) representing major pan-allergen families: Lipid Transfer Protein (LTP) family (Pru p 3), PR-10 proteins (Bet v 1, Pru p 1), and Profilins (Bet v 2, Pru p 4).

Main Results:

  • Sensitization to a pan-allergen significantly increases the odds of developing other allergies.
  • Co-sensitization patterns are dependent on the sensitizing pan-allergen family.
  • LTP sensitization showed a strong association with peanut sensitization.
  • PR-10 and Profilin sensitization were linked to hazelnut positivity.

Conclusions:

  • Pan-allergen sensitization is frequently associated with multiple co-sensitizations.
  • The specific pattern of co-sensitization is dictated by the sensitizing pan-allergen family.
  • These findings have implications for diagnostic strategies and understanding cross-reactivity in allergic diseases.