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Related Concept Videos

Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

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Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
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Trabecular bone score (TBS): Method and applications.

P Martineau1, W D Leslie2

  • 1University of Ottawa, Ottawa, Ontario, Canada.

Bone
|February 5, 2017
PubMed
Summary
This summary is machine-generated.

Trabecular bone score (TBS) offers insights into bone health beyond bone mineral density (BMD). Lower TBS predicts higher osteoporotic fracture risk, improving fracture prediction when combined with FRAX.

Keywords:
Bone textureDual-energy X-ray absorptiometryFractureOsteoporosisTrabecular bone score

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Area of Science:

  • Osteoporosis research
  • Medical imaging analysis
  • Bone health assessment

Background:

  • Trabecular bone score (TBS) is a novel index derived from DXA scans.
  • It quantifies bone texture, providing information independent of bone mineral density (BMD).
  • Existing fracture risk prediction tools like FRAX® have limitations.

Purpose of the Study:

  • To review the development, validation, and clinical utility of TBS.
  • To highlight TBS's role in improving osteoporotic fracture risk prediction.
  • To discuss TBS's application in guiding treatment decisions.

Main Methods:

  • Analysis of existing studies on TBS and fracture risk.
  • Evaluation of TBS derivation from DXA images.
  • Assessment of TBS-adjusted FRAX® probabilities.

Main Results:

  • Lower TBS values are consistently associated with increased major osteoporotic fracture risk.
  • This association is independent of BMD and other clinical risk factors.
  • TBS-adjusted FRAX® probabilities demonstrate improved accuracy in fracture risk prediction.

Conclusions:

  • TBS is a valuable tool for enhancing osteoporotic fracture risk assessment.
  • It complements BMD and FRAX® by providing independent information.
  • TBS aids in clinical decision-making for osteoporosis management, especially around intervention thresholds.