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Related Experiment Video

Updated: Mar 8, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Three-dimensional echocardiographic quantification of the left-heart chambers using an automated adaptive analytics

Diego Medvedofsky1, Victor Mor-Avi1, Mihaela Amzulescu2

  • 1University of Chicago, Medical Center, Chicago, Illinois, USA.

European Heart Journal. Cardiovascular Imaging
|February 5, 2017
PubMed
Summary

Automated three-dimensional echocardiography (3DE) accurately quantifies left heart chambers, offering a reproducible alternative to manual analysis. This advancement facilitates the integration of 3DE into routine clinical practice.

Keywords:
3D echocardiographyautomated analysiscardiac chamber quantificationmulticentre study

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Area of Science:

  • Cardiovascular Imaging
  • Echocardiography
  • Medical Technology

Background:

  • Current guidelines recommend three-dimensional echocardiography (3DE) for chamber quantification.
  • Clinical adoption of 3DE has been limited due to time-consuming manual analysis.
  • An automated algorithm for measuring left atrial (LA) and left ventricular (LV) volumes and ejection fraction (EF) has been developed.

Purpose of the Study:

  • To evaluate the accuracy and reproducibility of an automated 3DE chamber quantification algorithm.
  • To assess the performance of the automated method in a multicentre setting.

Main Methods:

  • 180 patients underwent 3DE imaging across six clinical sites.
  • Images were analyzed using automated HeartModel (HM) software and manual tracing.
  • Measurements were compared between automated HM (with and without corrections) and manual Core Laboratory (CL) analysis.

Main Results:

  • Automated HM showed strong correlations with manual CL measurements for LV volumes (LVEDV, LVESV), LVEF, and LA volume (LAV).
  • The automated technique demonstrated slight underestimations in LV volumes, LVEF, and LAV compared to manual tracing.
  • Automated measurements with corrections were more reproducible than manual measurements and showed improved accuracy.

Conclusions:

  • Automated 3DE analysis provides an accurate and reproducible alternative to conventional manual quantification of left heart chambers.
  • The consistency of automated measurements across laboratories supports its clinical utility.
  • This automated technique has the potential to facilitate the widespread integration of 3DE into routine clinical practice.