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The effects of synthetic cannabinoids on executive function
K Cohen1,2, M Kapitány-Fövény2,3,4, Y Mama1
1Department of Behavioral Science and Integrative Brain and Cognition Center, University of Ariel, Ariel, Israel.
Psychopharmacology
|February 5, 2017
Summary
Persistent use of synthetic cannabinoids is linked to significant executive function deficits, including memory and attention impairments, compared to cannabis users and non-users. These findings highlight the dangers of novel psychoactive substances.
Area of Science:
- Neuroscience
- Psychiatry
- Toxicology
Background:
- Novel psychoactive substances (NPSs), particularly synthetic cannabinoids, are increasingly prevalent.
- Synthetic cannabinoids mimic cannabis effects but are more potent and dangerous, leading to adverse outcomes.
Purpose of the Study:
- To investigate the association between chronic synthetic cannabinoid use and executive function impairments.
Main Methods:
- A comparative study involving 38 synthetic cannabinoid users, 43 recreational cannabis users, and 41 non-users.
- Utilized computerized cognitive tests: Stroop task, n-back task, and free-recall memory task.
Main Results:
- Synthetic cannabinoid users exhibited significantly poorer performance on n-back (accuracy), Stroop (speed and accuracy), and memory recall tasks.
- Elevated depression and anxiety ratings were observed in synthetic cannabinoid users compared to control groups.
Conclusions:
- Chronic synthetic cannabinoid use is associated with notable executive function deficits.
- These findings have significant implications for understanding the long-term neurological consequences of synthetic cannabinoid consumption.
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