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Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy
Quanyin Hu1,2, Wujin Sun1,2, Chenggen Qian1,2,3
1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Advanced Materials (Deerfield Beach, Fla.)
|February 5, 2017
Abstract:
A "relay drug delivery" system based on two distinct modules, which is composed of a signal transmission nanocarrier A (NCA ) that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B (NCB ) that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA , is developed for amplifying active tumor targeting signal and enhancing antitumor therapy.