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Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy

Michael Paulzen1, Ekkehard Haen2, Christoph Hiemke3

  • 1Department of Psychiatry, Psychotherapy and Psychosomatics, and JARA - Translational Brain Medicine, RWTH Aachen University, Aachen, Germany.

British Journal of Clinical Pharmacology
|February 5, 2017
PubMed
Summary

Combining antipsychotics like risperidone (RIS) and perazine increases drug interaction risks. Perazine significantly elevates RIS plasma levels and alters its metabolism, potentially by inhibiting CYP enzymes.

Keywords:
CYP2D6CYP3A4antipsychotic polypharmacycytochrome P450interactionperazinepharmacokineticsrisperidonetherapeutic drug monitoring

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