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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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[Focus on the Immunoscore and its potential clinical implications].

Carine El Sissy1, Florence Marliot1, Nacilla Haicheur2

  • 1Immunologie et cancérologie intégrative, Inserm UMRS1138, centre de recherche des Cordeliers, 15, rue de l'École-de-Médecine, 75006 Paris, France; Université Paris Descartes, 45, rue des Saints-Pères, 75006 Paris, France; Centre de recherche des Cordeliers, université Pierre-et-Marie-Curie Paris 6, 15, rue de l'École-de-Médecine, 75006 Paris, France; Plateforme d'immunomonitoring, laboratoire d'immunologie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.

Annales De Pathologie
|February 6, 2017
PubMed
Summary

The tumor microenvironment's immune contexture, including T cells, significantly impacts cancer prognosis. Immunoscore quantifies this immune response, showing prognostic value in colon cancer.

Keywords:
Cancer colorectalColorectal cancerImmunoscorePrognosisPronostic

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • The tumor immune microenvironment is critical for cancer patient outcomes.
  • Immune cell type, function, density, and location (immune contexture) influence prognosis.
  • A Th1-polarized microenvironment with cytotoxic and memory T cells is linked to better outcomes.

Purpose of the Study:

  • To introduce and validate Immunoscore, a test measuring intra- and peritumoral immune response.
  • To assess the prognostic value of Immunoscore in colon cancer.

Main Methods:

  • Development of Immunoscore to quantify immune cell parameters within tumors.
  • Validation through a large international retrospective study in colon cancer patients.

Main Results:

  • Immunoscore provides a simple, reproducible, and robust measure of the immune response.
  • The prognostic value of Immunoscore has been validated in colon cancer.

Conclusions:

  • Immunoscore demonstrates significant prognostic value in colon cancer.
  • Potential clinical applications include prognostic and theranostic uses for cancer patients.