Related Experiment Video
Updated: Mar 8, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Systemic lupus erythematosus and contraception: A systematic literature review]
N Gensous1, L Doassans-Comby2, E Lazaro3
1Service de médecine interne et immunologie clinique, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France; UMR CNRS 5164, université de Bordeaux, 146, rue Léo-Saignat, 33076 Bordeaux, France.
Objective:
The aim of our study was to evaluate the safety of contraceptive methods use among women with systemic lupus erythematosus (SLE).
Methods:
A systematic review of the literature was performed using the two databases MEDLINE and SCOPUS, in order to identify articles concerning the safety of contraceptive methods use among women with SLE, through May 2016. Information on study characteristics, objectives, population, contraception and outcomes were extracted.
Results:
A total of 907 articles were identified and 21 were selected for the systematic review. Two randomised controlled trials found no worsening of disease activity with the use of combined oral contraceptive in women with stable or inactive SLE. Disease activity was not exacerbated with the use of progestogens-only contraceptive. There was an increased risk of thrombosis with the use of combined contraceptive, particularly in women with positive antiphospholipid antibodies and this must lead to a restriction of use in these patients.
Conclusion:
Use of oral combined hormonal contraceptives should be limited to patients with non-severe and stable disease, without thrombosis risk factors.
Related Concept Videos
01:22Birth Control Methods
01:21Intrauterine Drug Delivery Systems
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...