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Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder
Shinji Fukui1, Katsuya Aoki1, Yosuke Morizawa1
1Department of Urology, Nara Medical University, Nara, Japan.
Urology
|February 6, 2017
Summary
Urinary nerve growth factor (NGF) levels are higher in children with overactive bladder (OAB). Elevated urinary NGF/creatinine (Cr) also predicts treatment resistance in pediatric OAB patients.
Area of Science:
- Pediatric Urology
- Biomarkers in Urology
- Urologic Oncology
Background:
- Overactive bladder (OAB) is a common condition in children, characterized by urinary urgency and frequency.
- Current diagnostic methods for pediatric OAB lack specific biomarkers, necessitating further research into objective indicators.
- Nerve growth factor (NGF) plays a role in bladder function and has been implicated in various lower urinary tract conditions.
Purpose of the Study:
- To evaluate urinary nerve growth factor (NGF) levels in children diagnosed with overactive bladder (OAB).
- To determine the correlation between urinary NGF normalized to creatinine (NGF/Cr) and the presence and severity of OAB in pediatric patients.
- To explore the potential of urinary NGF/Cr as a predictor of treatment response in children with OAB.
Main Methods:
- A cohort of 35 children with OAB and 11 healthy controls were enrolled.
- Urinary NGF levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Urinary NGF concentrations were normalized to urinary creatinine (NGF/Cr) and compared between groups, including refractory OAB cases.
Main Results:
- Children with OAB exhibited significantly higher urinary NGF/Cr levels compared to the control group (P=.0007).
- A significant elevation in urinary NGF/Cr was observed in children with refractory OAB compared to those who showed symptom improvement (P=.027).
- Approximately 74% of children with OAB experienced symptom improvement with treatment, while 26% had refractory symptoms.
Conclusions:
- Urinary NGF/Cr levels are significantly elevated in children suffering from overactive bladder.
- Higher urinary NGF/Cr levels are associated with treatment-refractory OAB in pediatric patients.
- Urinary NGF/Cr shows promise as a potential biomarker for diagnosing pediatric OAB and predicting therapeutic outcomes.
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