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Holder pasteurization affects S100B concentrations in human milk.

Chiara Peila1, Alessandra Coscia1, Enrico Bertino1

  • 1a Neonatology Unit, Department of Public Health and Pediatrics , University of Turin , Turin , Italy.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|February 7, 2017
PubMed
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Holder pasteurization significantly reduces S100B neurobiomarker levels in donor milk. This study highlights the impact of pasteurization on crucial brain development factors in human milk, necessitating improved preservation methods.

Area of Science:

  • Neonatal nutrition
  • Human milk research
  • Neurobiology

Background:

  • Donor milk (DM) is vital for high-risk newborns.
  • Holder pasteurization (HoP) is standard for DM safety but may affect biological quality.
  • Effects of HoP on neurobiomarkers (NB) in DM are unknown.

Purpose of the Study:

  • To investigate the impact of Holder pasteurization (HoP) on S100B neurobiomarker concentrations in donor milk.
  • To assess if HoP alters levels of S100B, a key factor in brain development and damage.

Main Methods:

  • A pretest-posttest design was used with 11 mothers' donor milk samples.
  • Samples were divided: one immediately frozen, the other Holder pasteurized before freezing.
  • S100B levels were quantified using an immunoluminometric assay.
Keywords:
Central nervous systemS100Bdonor human milkhuman milkpasteurization holder

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Main Results:

  • S100B protein was detected in all tested donor milk samples.
  • Holder pasteurization resulted in statistically significant differences (p < 0.05) in S100B levels.

Conclusions:

  • S100B is present in human milk across maturation stages.
  • Pasteurization significantly affects S100B levels, indicating susceptibility to heat treatment.
  • New methods are needed to preserve the biological quality of human milk during processing.