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Associations between urinary diphenyl phosphate and thyroid function.

Emma V Preston1, Michael D McClean1, Birgit Claus Henn1

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PubMed
Summary
This summary is machine-generated.

Triphenyl phosphate (TPHP) exposure, measured via its metabolite diphenyl phosphate (DPHP) in urine, was linked to higher total thyroxine (TT4) levels, particularly in women. This suggests a potential impact on thyroid function from common flame retardant exposure.

Keywords:
Diphenyl phosphateOrganophosphate flame retardantsThyroid hormonesTriphenyl phosphate

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Area of Science:

  • Environmental Health
  • Toxicology
  • Endocrinology

Background:

  • Triphenyl phosphate (TPHP) is a widely used flame retardant and plasticizer with significant human exposure.
  • Existing data on TPHP's health effects are limited, but recent studies suggest potential thyroid function disruption.
  • Urinary diphenyl phosphate (DPHP) serves as a biomarker for TPHP exposure.

Purpose of the Study:

  • To assess the temporal variability of urinary DPHP concentrations in adults.
  • To investigate the relationship between DPHP levels and key thyroid hormones (fT4, TT4, TT3, TSH).
  • To explore potential sex-specific differences in these associations.

Main Methods:

  • Longitudinal study involving 51 adults sampled at three time points over one year.
  • Urine samples analyzed for DPHP; serum samples analyzed for thyroid hormones.
  • Statistical analysis included intraclass correlation coefficients (ICCs), kappa statistics, and linear mixed-effects models.

Main Results:

  • DPHP was detected in 95% of urine samples, with higher mean concentrations observed in women.
  • High DPHP levels were significantly associated with increased total thyroxine (TT4) in all participants.
  • This association was more pronounced in women, with no significant links found for fT4, TT3, or TSH.

Conclusions:

  • TPHP exposure, indicated by urinary DPHP, may be associated with elevated TT4 levels.
  • Women may be more susceptible to the thyroid-altering effects of TPHP exposure.
  • Further research is warranted to fully elucidate the endocrine-disrupting potential of TPHP.