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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Positive Regulator Molecules02:39

Positive Regulator Molecules

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

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The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Meiosis II02:02

Meiosis II

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Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
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CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development.

Sami Zaqout1, Paraskevi Bessa2, Nadine Krämer1

  • 1Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Center for Chronically Sick Children (Sozialpädiatrisches Zentrum, SPZ), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health (BIH), Kapelle-Ufer 2, 10117 Berlin, Germany.

Stem Cell Reports
|February 7, 2017
PubMed
Summary

The gene Cdk5rap2 is crucial for maintaining embryonic germ cells. Mutations lead to male infertility in mice due to defects in germ cell development and increased apoptosis.

Keywords:
CDK5RAP2MCPHapoptosiscell cyclegermlineinfertilityintellectual disabilitymicrocephalymitotic delay

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Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
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Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
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Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
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Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
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Area of Science:

  • Developmental biology
  • Genetics
  • Reproductive biology

Background:

  • Gene products associated with microcephaly are primarily studied for brain development roles.
  • The function of these genes in other organ development, such as germ cells, is under-investigated.

Purpose of the Study:

  • To investigate the role of Cdk5rap2 in embryonic germ cell development.
  • To understand the cause of infertility in Cdk5rap2 mutant mice.

Main Methods:

  • Analysis of Cdk5rap2 mutant mice.
  • Assessment of germ cell pool maintenance during embryonic development.
  • Evaluation of germ cell cycle progression and apoptosis.

Main Results:

  • Cdk5rap2 plays a critical role in maintaining the embryonic germ cell pool.
  • Cdk5rap2 mutant mice exhibit a lack of spermatogenic cells in adulthood.
  • Germ cell defects in mutants include mitotic delay, prolonged cell cycle, and apoptosis.

Conclusions:

  • Cdk5rap2 is essential for normal germ cell development and male fertility.
  • The study reveals a previously unrecognized function of Cdk5rap2 beyond brain development.