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Published on: October 27, 2020
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Long noncoding RNA activated by TGF-β in human cancers: A meta-analysis
Yang-Hua Fan1, Chen-Xing Ji1, Bing Xu1
1Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 7, 2017
Summary
Increased expression of long non-coding RNA ATB (activated by TGF-β) is linked to poorer outcomes in many cancers. This finding suggests lncRNA-ATB is a potential prognostic biomarker for human malignancies.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Research
Background:
- Long non-coding RNA ATB (activated by TGF-β) is frequently dysregulated in various cancers.
- Its prognostic significance in malignant tumors requires comprehensive evaluation.
Purpose of the Study:
- To conduct a meta-analysis evaluating the prognostic value of lncRNA-ATB expression in human cancers.
- To correlate lncRNA-ATB expression with overall survival and clinicopathological features.
Main Methods:
- Systematic literature search of major databases (PubMed, Medline, Ovid, Cochrane, Web of Science) up to November 2016.
- Meta-analysis of eight studies involving 818 cancer patients.
- Statistical analysis of hazard ratios (HRs) for survival and odds ratios (ORs) for clinicopathological parameters using RevMan5.3 software.
Main Results:
- Elevated lncRNA-ATB expression significantly correlated with poorer overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS).
- Increased lncRNA-ATB was associated with lymph node metastasis (LNM), distant metastasis (DM), and advanced tumor stage.
- These associations were observed in various cancers, excluding pancreatic cancer.
Conclusions:
- The meta-analysis indicates that high lncRNA-ATB expression serves as a valuable prognostic biomarker in human cancers.
- lncRNA-ATB dysregulation is a significant indicator of adverse clinical outcomes and disease progression.
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