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Updated: Mar 8, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Reference ranges of placental volume measured by virtual organ computer-aided analysis between 10 and 14 weeks of
Daranee Meengeonthong1, Suchaya Luewan1, Supatra Sirichotiyakul1
1Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University, Thailand.
Objective:
To establish the reference ranges of the placental volume between 10 and 14 weeks of gestation of Thai fetuses.
Methods:
The placental volumes were acquired in normal pregnancies between 10 and 14 weeks of gestation using transabdominal three-dimensional ultrasound. The placental volume was then analyzed using VOCAL (virtual organ computer-aided analysis) technique with a rotation angle of 30°. The measured values were regressed to identify the best-fit model.
Results:
A total of 236 volume datasets met the inclusion criteria and were used for offline analysis. Placental volume significantly increased with increasing crown-rump length (CRL). The best-fit regression models for predicted mean and SD as a function of CRL, available for z score calculation and construction of the percentile chart, are as follows: [Formula: see text] CONCLUSION: Reference ranges of placental volume have been constructed. This normative data may be a useful tool in the evaluation of various conditions affecting placental size, eg, fetal hemoglobin Bart's disease. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:185-191, 2017.
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