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Assessment of Mean Platelet Volume and its Effect on Disease Control in Patients with Acromegaly

Dilek Arpaci, Fatih Kuzu, Mustafa Unal

    Clinical Laboratory
    |February 7, 2017
    PubMed

    Insights

    Acromegaly patients show higher mean platelet volume (MPV) levels, indicating increased platelet activation and cardiovascular risk. This difference persists until early treatment stages, suggesting MPV as a potential biomarker.

    Area of Science:

    • Endocrinology
    • Cardiology
    • Hematology

    Background:

    • Cardiovascular diseases are more prevalent in acromegaly patients.
    • Platelets are implicated in clotting and atherosclerosis development.
    • Elevated mean platelet volume (MPV) signifies platelet activation and is a risk factor for atherosclerosis.

    Purpose of the Study:

    • To compare MPV levels between acromegalic and non-acromegalic individuals.
    • To investigate MPV as a potential indicator of cardiovascular risk in acromegaly.

    Main Methods:

    • Retrospective review of data from 56 acromegalic patients and 72 controls.
    • Controls were matched for age, gender, and diabetes status.
    • MPV levels were analyzed at diagnosis and after six months of treatment.

    Main Results:

    • Acromegalic patients exhibited significantly higher MPV levels than controls (8.82 ± 1.17 fL vs. 7.74 ± 0.87 fL, p < 0.001).
    • MPV levels did not show significant changes at diagnosis or after six months of treatment.
    • No significant difference in MPV was observed based on remission status.

    Conclusions:

    • MPV levels are elevated in acromegalic patients compared to controls, independent of diabetes.
    • Elevated MPV may serve as an important determinant of cardiovascular risk in acromegaly.
    • MPV could be a valuable biomarker in managing acromegalic patients.
    Abstract

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