Specific Skin Involvement in Leukaemias and Lymphomas

Area of Science:

• Hematology
• Dermatology
• Oncology

Background:

• Cutaneous involvement is a known complication of hematologic malignancies.
• The spectrum of skin lesions associated with these cancers can be diverse.
• Understanding these dermatological signs is crucial for early diagnosis.

Purpose of the Study:

• To investigate the relationship between specific skin lesions and hematologic malignancies.
• To correlate histopathological findings of skin infiltrates with diagnosed cancers.

Main Methods:

• Case series involving patients with leukemia, non-Hodgkin's lymphoma, and Hodgkin's lymphoma.
• Clinical examination to document skin lesions (maculo-papular rashes, papules, nodules, urticarial lesions, plaques).
• Histopathological analysis of skin biopsies to identify specific cellular infiltrates.

Main Results:

• Four cases of leukemia, five of non-Hodgkin's lymphoma, and three of Hodgkin's lymphoma presented with various skin lesions.
• Histopathology revealed distinct skin infiltrates in all cases, corresponding to the specific type of malignancy.
• Observed lesions included maculo-papular rashes, papules, nodules, urticarial skin lesions, and plaques.

Conclusions:

• Specific cutaneous infiltrates observed on histopathology can be indicative of underlying hematologic malignancies.
• Dermatological manifestations should be considered in the diagnostic workup of patients with suspected or confirmed blood cancers.
• This highlights the importance of integrating dermatological and hematological assessments.