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Unusual Side Effects of Systemic 5-fluorouracil
Indian Journal of Dermatology, Venereology and Leprology
|February 7, 2017
Summary
Photosensitivity and nail pigmentation are potential side effects of 5-fluorouracil (5-FU) chemotherapy. These symptoms resolved upon drug discontinuation and reappeared with re-administration in a patient with adenocarcinoma.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Systemic 5-fluorouracil (5-FU) is a widely used chemotherapeutic agent for various cancers, including colorectal adenocarcinoma.
- Adverse drug reactions associated with 5-FU can manifest in various ways, impacting patient quality of life.
Observation:
- A 55-year-old male patient diagnosed with adenocarcinoma of the caecum presented with notable photosensitivity and temporary nail pigmentation.
- These dermatological side effects emerged during the course of systemic 5-FU treatment.
Findings:
- The observed photosensitivity and nail pigmentation were directly attributed to the administration of 5-fluorouracil.
- Discontinuation of 5-FU led to the complete resolution of these adverse effects.
- Re-initiation of 5-FU therapy resulted in the recurrence of the photosensitivity and nail pigmentation, confirming the drug's role.
Implications:
- This case highlights the importance of recognizing and managing dermatological side effects of 5-fluorouracil in cancer patients.
- Awareness of these potential reactions can aid clinicians in patient counseling and treatment adjustments.
- Further investigation into the mechanisms of 5-FU-induced photosensitivity and nail changes may be warranted.
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