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Reduction in OKT6 Positive Epidermal Langerhans Cells in Psoriasis

R B Narayanan, B K Girdhar

    Indian Journal of Dermatology, Venereology and Leprology
    |February 7, 2017
    PubMed

    Lengerhans cells (LC) were defined by indirect immunoperoxidast using OKT6 monoclonal antibody m the skin lesions of 10 untreated psoriasis patients. The distribution and the numbers of OKT6 + epidermal LC in the lesions was low in comparison to that found in the normal skin. In some of the lesions, T6 + LC could not be seen in the epidermis. This observation suggests that the reduction in LC may be a contributing factor in the pathogenesis of psoriasis.

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