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Related Experiment Video

Updated: Mar 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Published on: July 11, 2013

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Modified Dithranol Therapy for Psoriasis.

Lnderjeet Kaur, Surrinder Kaor, Vinod Sharma

    Indian Journal of Dermatology, Venereology and Leprology
    |February 7, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Dithranol ointment effectively treated plaque psoriasis in 107 patients. Most achieved clear skin with 0.25% concentration, with mild side effects like skin irritation reported.

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    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Psoriasis vulgaris is a chronic inflammatory skin condition.
    • Topical treatments are a cornerstone of psoriasis management.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of a graded concentration of dithranol ointment for plaque psoriasis.
    • To determine optimal dithranol concentrations for lesion clearance.

    Main Methods:

    • 107 patients with plaque psoriasis received dithranol ointment with gradually increasing concentrations.
    • Application involved evening application, sun exposure the next day, followed by bathing.
    • Treatment continued for up to 16 weeks or until lesions cleared.

    Main Results:

    • Complete clearance was observed in 54 patients; 22% showed 75% clearance.
    • Majority required 0.25% concentration; a few needed 0.5%.
    • Legs and elbows were resistant sites; mild local side effects (folliculitis, irritation) occurred, with 7 patients discontinuing therapy.

    Conclusions:

    • Graded dithranol ointment is an effective treatment for plaque psoriasis, with most patients clearing at 0.25% concentration.
    • The treatment is generally well-tolerated, with manageable local side effects.
    • Further research could explore optimizing application protocols for resistant sites.