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Basophil Activation Test for Allergy Diagnosis

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Anaphylactic Reaction To Mantoux Test.

Indian Journal of Dermatology, Venereology and Leprology

|February 7, 2017

Summary

This summary is machine-generated.

A severe allergic reaction, known as anaphylaxis, occurred after a Mantoux test for tuberculosis. Repeated testing worsened the hypersensitivity reactions in a 17-year-old girl.

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Area of Science:

Immunology
Allergy Research
Diagnostic Testing

Background:

The Mantoux test, using purified protein derivative (PPD), is a standard method for tuberculosis screening.
Type I hypersensitivity reactions involve an immediate immune response to an antigen.

Observation:

A 17-year-old female experienced an anaphylactic reaction post-Mantoux testing.
The patient showed no prior indicators of tuberculosis infection.

Findings:

The anaphylactic reaction was a direct result of the purified protein derivative antigen used in the Mantoux test.
Subsequent administrations of the test antigen led to progressively more severe hypersensitivity responses.

Implications:

This case highlights the potential for severe allergic reactions to diagnostic antigens.
It underscores the importance of considering individual hypersensitivity profiles in diagnostic procedures.
Further research into PPD-specific hypersensitivity mechanisms may be warranted.