Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

519
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
519
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

564
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
564
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.0K
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

821
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
821
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.9K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.9K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

964
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
964

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial Epidermolysis Bullosa Pruriginosa.

Indian dermatology online journal·2023
Same author

Myths, misconceptions and attitudinal trends among patients with acne.

Indian journal of dermatology, venereology and leprology·2022
Same author

Erythromelanosis follicularis faciei et colli: a clinicoepidemiological study.

International journal of dermatology·2022
Same author

Cyclosporine in Cholinergic Itch.

Indian dermatology online journal·2022
Same author

Cyclosporine in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Experience from a Tertiary Care Centre of South Rajasthan.

Indian dermatology online journal·2021
Same author

Cyclosporine in treatment of progressive vitiligo: An open-label, single-arm interventional study.

Indian journal of dermatology, venereology and leprology·2019
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network
09:54

High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network

Published on: January 29, 2018

11.6K

Plica Neuropathica.

Ashok Kumar Khare

    Indian Journal of Dermatology, Venereology and Leprology
    |February 7, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Plica neuropathica, a rare nerve condition, can develop after prolonged mental distress. This case highlights a potential link between psychological stress and neuropathic symptoms.

    More Related Videos

    Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
    08:40

    Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

    Published on: May 2, 2019

    6.4K
    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
    09:39

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

    10.2K

    Related Experiment Videos

    Last Updated: Mar 7, 2026

    High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network
    09:54

    High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network

    Published on: January 29, 2018

    11.6K
    Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
    08:40

    Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

    Published on: May 2, 2019

    6.4K
    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
    09:39

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

    10.2K

    Area of Science:

    • Neurology
    • Psychiatry
    • Dermatology

    Background:

    • Plica neuropathica is a poorly understood condition characterized by neuropathic pain.
    • The etiology of plica neuropathica is not well-established, with limited research on contributing factors.

    Observation:

    • A case study of an adult female presenting with symptoms of plica neuropathica.
    • The patient experienced prolonged periods of significant mental distress prior to symptom onset.

    Findings:

    • The development of plica neuropathica was observed in the context of severe psychological stress.
    • This suggests a potential psychoneurological link in the manifestation of this condition.

    Implications:

    • This case underscores the importance of considering psychological factors in the diagnosis and management of neuropathic conditions.
    • Further research is warranted to explore the relationship between mental health and plica neuropathica.
    • Understanding this connection may lead to novel therapeutic strategies targeting both psychological and neurological aspects.