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Updated: Mar 7, 2026

Dissection of the Endolymphatic Sac from Mice
Published on: March 29, 2021
β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its
Bo Gyung Kim1, Jin Young Kim2, JinSei Jung3
1Department of Otorhinolaryngology, Soonchunhyang University College of Medicine, Bucheon, 420-767, Republic of Korea.
Abstract:
The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere's disease. Herein, we found, for the first time, functional evidence for the involvement of β1- and β2-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K+ and Cl- ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere's disease. These results suggested that adrenergic stimulation via β1- and β2-adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere's disease.
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