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Sebaceous Carcinoma Treated With Mohs Micrographic Surgery
Kimberly L Brady1, Eva A Hurst
1*Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
Summary
Mohs micrographic surgery effectively treated sebaceous carcinoma, showing no recurrences or deaths. Genetic testing and history are key for identifying Muir-Torre syndrome (MTS).
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Sebaceous carcinoma is a rare, aggressive adnexal neoplasm.
- Historically associated with high recurrence, metastasis, and mortality rates.
Purpose of the Study:
- Evaluate local recurrence, metastasis, and mortality in sebaceous carcinoma patients treated with Mohs surgery.
- Identify optimal diagnostic work-up approaches for this condition.
Main Methods:
- Retrospective review of 45 sebaceous carcinomas in 37 patients treated between 2001-2013.
- Analysis of tumor locations, patient demographics, and follow-up data.
- Assessment of Muir-Torre syndrome (MTS) and mismatch repair gene expression.
Main Results:
- No local recurrences, metastases, or disease-specific deaths observed over a 3.6-year follow-up.
- Muir-Torre syndrome (MTS) or Lynch syndrome identified in 5 patients.
- Immunohistochemical analysis revealed loss of mismatch repair gene expression in 7 of 12 tumors.
Conclusions:
- Mohs micrographic surgery demonstrates efficacy in treating sebaceous carcinoma.
- Thorough medical history, cancer screening, and genetic testing aid in MTS identification.
- Referral to a geneticist is recommended for patients with suspected MTS.
