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Related Concept Videos

Constant Pressure Calorimetry03:02

Constant Pressure Calorimetry

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Calorimetry is a technique used to measure the amount of heat involved in a chemical or physical process or to measure the heat transferred to or from a substance. The heat is exchanged with a calibrated and insulated device called the calorimeter. Calorimetry experiments are based on the assumption that there is no heat exchange between the insulated calorimeter and the external environment. The well-insulated calorimeters prevent the transfer of heat between the calorimeter and its external...
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Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
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When objects at different temperatures are placed in contact with each other but isolated from everything else, they attain thermal equilibrium. A container that prevents heat transfer in or out is called a calorimeter, and the use of a calorimeter to make measurements is called calorimetry. Generally, these measurements involve heat or specific heat capacity. The term "calorimetry problem" is used for any problem where the specified objects are thermally isolated from their...
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Thermal Measurement Techniques in Analytical Microfluidic Devices
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A Multichannel Calorimetric Simultaneous Assay Platform Using a Microampere Constant-Current Looped Enthalpy Sensor

Hsien-Chin Wei1, Su-Hua Huang2, Joe-Air Jiang3,4,5

  • 1Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei 10617, Taiwan. d94631001@ntu.edu.tw.

Sensors (Basel, Switzerland)
|February 7, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel multichannel calorimetric simultaneous assay (MCSA) platform for high-throughput biochemical measurements. The MCSA platform utilizes an adjustable microampere constant-current source, overcoming limitations of traditional Wheatstone bridge amplifiers for enhanced biochemical analysis.

Keywords:
adjustable microampere constant current loopcatalaseenthalpy sensor arraymultichannel calorimeterrelative enzyme activitysimultaneous assay

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Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Instrumentation

Background:

  • Calorimetric biochemical measurements offer advantages like low waste, cost, and sample consumption.
  • Multichannel calorimeters increase throughput for biochemical assays.
  • Existing enthalpy sensor (ES) arrays often use Wheatstone bridge amplifiers, limiting their application to low resistance sensors and null detection.

Purpose of the Study:

  • To develop a novel multichannel calorimetric simultaneous assay (MCSA) platform.
  • To overcome the limitations of traditional Wheatstone bridge amplifiers in enthalpy sensor signal conditioning.
  • To create a flexible and powerful device for higher-throughput biochemical measurements.

Main Methods:

  • Designed an adjustable microampere constant-current (AMCC) source for exciting the ES array.
  • Employed a microampere current loop measurement circuit topology.
  • Integrated a multichannel calorimeter and automatic injector with multichannel ES signal conditioners and a data processor into a single block.

Main Results:

  • Evaluated the performance of the MCSA platform, including current stability, temperature sensitivity, and heat sensitivity.
  • Determined sensor response time and calorimeter constants.
  • Demonstrated the platform's capability to detect relative enzyme activity, showing higher throughput than existing methods.

Conclusions:

  • The developed MCSA platform is a flexible and powerful biochemical measurement device.
  • The AMCC source and microampere current loop topology effectively condition ES signals.
  • The MCSA platform offers significantly higher throughput for biochemical assays compared to current alternatives.