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Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical

Xing Wang1, Sharjeel A Chaudhry2, Wensheng Hou3

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wangxing@cqu.edu.cn.

International Journal of Molecular Sciences
|February 7, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a new wireless implantable device for electrical epidural cortical stimulation, showing promise for stroke rehabilitation. The device successfully modulated brain responses in cats, demonstrating its potential for advanced neurological research and therapy.

Keywords:
epidural cortical stimulationinductive couplingmicro coilnerve-electrode interfacerehabilitationstroke

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Rehabilitation Technology

Background:

  • Stroke rehabilitation therapy can be significantly improved by electrical epidural cortical stimulation.
  • Developing effective and minimally invasive stimulation methods is crucial for advancing stroke recovery.
  • Existing methods may lack the flexibility and wireless capabilities needed for optimal therapeutic application.

Purpose of the Study:

  • To develop and evaluate a preliminary wireless implantable passive interface for electrical epidural cortical stimulation.
  • To assess the feasibility of using this interface for stimulating the primary visual cortex (V1) and recording evoked responses.
  • To demonstrate the device's capability to deliver adjustable and stable electrical stimuli.

Main Methods:

  • A wireless implantable passive interface was designed using flexible printed circuit (FPC) technology, incorporating a stimulating electrode and a receiving coil.
  • The interface was implanted in the epidural space of cats for unilateral V1 stimulation.
  • Evoked responses, specifically cortico-cortical evoked potentials (CCEPs), were recorded from the contralateral V1 using a needle electrode.
  • Stimulation intensity was adjusted by controlling the transmitter circuit voltage (5-20 V).

Main Results:

  • The wireless implantable board successfully delivered stable monophasic voltage stimuli.
  • Cortico-cortical evoked potential (CCEP) responses were recorded in the contralateral V1.
  • The amplitude of the N2 component in CCEP was significantly modulated by adjusting the stimulation intensity of the wireless interface.
  • The dura mater-electrode interface effectively transmitted electrical stimulation.

Conclusions:

  • The developed wireless interface, based on a microcoil array, is a valuable tool for researchers exploring electrical stimulation.
  • This technology shows potential for advancing stroke rehabilitation and neurological research.
  • The system demonstrates effective electrical stimulation delivery and response modulation through a wireless, implantable interface.