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Neuroprotective effects of extracellular DJ-1 on reperfusion injury in SH-SY5Y cells
Jay Han1, Beryl Luk1, Frank J S Lee1
1Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Abstract:
Using an in vitro model of ischemic stroke we treated differentiated SH-SY5Y cells to oxygen-glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ-1 during reperfusion exhibited significant rescue from OGD-induced cell death.
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