Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fumarate Hydratase-deficient Renal Cell Carcinoma - A Multicentric Comprehensive Clinical, Pathological, and Molecular Analysis of 12 Cases.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026

Same author

Promises and Pitfalls of Whole Exome Sequencing in Therapy-Resistant Chronic Thrombocytopenia in Childhood: A Case Report.

Journal of personalized medicine·2026

Same author

Optical coherence tomography angiography parameters in Marfan syndrome: Genetic determinants and associations with cardiovascular manifestations.

PloS one·2026

Same author

Cholesteryl esters and high protein-to-lipid ratios distinguish non-vesicular extracellular particles from extracellular vesicles.

Cell communication and signaling : CCS·2026

Same author

Updated consensus guidelines for the diagnosis and management of patients with HCL and HCL variant.

Blood·2026

Same author

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study.

The journal of pathology. Clinical research·2026

Search research articles

Related Experiment Video

Updated: Mar 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

[TP53 mutation analysis in chronic lymphocytic leukaemia].

Viktória Fésüs¹, Dóra Marosvári¹, Béla Kajtár²

¹I. Patológiai és Kísérleti Rákkutató Intézet, Magyar Tudományos Akadémia-Semmelweis Egyetem Lendület Molekuláris Onkohematológia Kutatócsoport, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.

|February 8, 2017

Summary

Screening for TP53 mutations alongside 17p deletions in chronic lymphocytic leukemia (CLL) identifies more high-risk patients. This comprehensive TP53 defect analysis is crucial for effective treatment selection.

Keywords:

TP53 chronic lymphocytic leukaemia célzott terápia krónikus lymphocytás leukaemia targeted therapy

More Related Videos

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Related Experiment Videos

Last Updated: Mar 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Area of Science:

Oncology
Hematology
Genetics

Background:

Innovative therapies for chronic lymphocytic leukemia (CLL) show efficacy in patients with TP53 abnormalities.
Identifying TP53 defects, including 17p deletions and TP53 mutations, is essential for patient management.

Purpose of the Study:

To determine the frequency of TP53 mutations and their association with 17p deletions in a Hungarian cohort of 196 CLL patients.

Main Methods:

TP53 mutation analysis was conducted on exons 3-10 using Sanger sequencing.

Main Results:

TP53 mutations were found in 15.8% of patients, with half co-occurring with 17p deletions.
Combined analysis of TP53 mutations and 17p deletions identified TP53 defects in 25.4% of the cohort.

Conclusions:

TP53 mutation analysis detects an additional 10% of high-risk CLL patients.
Comprehensive TP53 defect screening is vital for optimizing treatment strategies in CLL.