Related Experiment Video
Updated: Mar 7, 2026

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
Published on: February 21, 2025
Comparison of low-dose coronary artery calcium scoring using low tube current technique and hybrid iterative
Nada Sulaiman1, Jeanette Soon1, Jong Kwan Park1
1St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Introduction:
We sought to validate whether low dose CACS CT with hybrid IR (HIR) could replace standard dose filtered back projection (FBP).
Method:
We enrolled 100 patients to undergo low dose CACS CT with HIR, in addition to routine full dose FBP.
Results:
No significant difference between full and low dose CT in Agatston score 138.2±360.6 vs. 137.3±356.4 (p=0.272) or calcium mass score 19±48.3 vs. 18.7±49 (p=0.8), respectively. Bland-Altman analysis showed no systematic bias. Calcium volume difference was statistically significant 57.2±134 vs. 55.1±130.2 (p=0.001).
Conclusion:
Low dose CT for calcium scoring with HIR enables stable CACS Agatston score and calcium mass quantification as compared to full dose FBP.
Related Concept Videos
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Imaging Studies for Cardiovascular System V: CT
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

